منابع مشابه
Lost in transdifferentiation.
What are the true origins of the smooth muscle cells (SMCs) present in the intimal lesions of transplant arteriosclerosis? A new study in the JCI shows that Sca-1(+) cells purified from the mouse aortic root can migrate through an irradiated vein graft to the neointima of the vessel and transdifferentiate to express the early SMC differentiation marker gene SM22. Do Sca-1(+) cells transdifferen...
متن کاملKinetic barriers in transdifferentiation.
Feature to: Jiang H. et al. Cell cycle and p53 gate the direct conversion of human fibroblasts to 2 The unidirectional and deterministic development of a zygote to trillions of cells that constitute a human produces the impression that it is an irreversible process, perhaps driven by reduction in free energy (G), as postulated in the Waddington Model, the prevailing doctrine in developmental b...
متن کاملIs transdifferentiation in trouble?
Spectacular examples of transdifferentiation--such as brain cells turning to blood and blood to brain--have given way to sneaking suspicions about artifacts in culture, fusion, and clonality. Could cell fates be relatively fixed after all?
متن کاملLost iPhone? Lost Passwords!
The paper highlights risks that accompany losing a locked iOS device regarding confidentiality of passwords stored in the keychain. It presents results of handson tests that show the possibility for attackers to reveal some of the keychain entries. For the described approach, the knowledge of the user’s secret passcode is not needed, as the protection provided by the passcode is bypassed.
متن کاملTransdifferentiation--fact or artifact.
Normal development appears to involve a progressive restriction in developmental potential. However, recent evidence suggests that this progressive restriction is not irreversible and can be altered to reveal novel phenotypic potentials of stem, progenitor, and even differentiated cells. While some of these results can be explained by the presence of contaminating cell populations, persistence ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2004
ISSN: 0021-9738
DOI: 10.1172/jci200421761